Bailey Bonet: Streptomyces Interspecies Interaction Mechanisms

Streptomyces produce a myriad of specialized metabolites from which many important antibiotics have been derived. Although little is known about the ecological role of these secondary metabolites, they seem to be important in mediating interspecies interactions. During interactions, S. coelicolor displays specificity for the specialized metabolites it produces leading to highly complex interactions. My project uses genetics, analytical chemistry, and co-culturing techniques to understand how S. coelicolor regulates specialized metabolite production during these interactions. This understanding can allow us to tap into the numerous silent specialized metabolite biosynthetic gene clusters and also give us insight into their ecological role.